The potential impression of fructo-oligosaccharides and zinc oxide nano composite against nicotine influenced cardiovascular changes

Abstract

Nicotine is easily transported to heart through blood and it increase the risk of coronary artery diseases by twofold besides developing a hyper-coagulable state (through platelets aggregation or fat deposition in artery), increased heart rate and blood, free radicals’ generation, increased cardiac stress, etc. Nutritional therapy establishes nutrients’ health potential without side effects. Fructo-oligosaccharides (functional soluble fiber) are capable of producing a higher amount of short-chain fatty acid (SCFA: fermented product) in the GI tract than other fibers. Zinc is an abundant metal for physiological and biological activities. A new fructo-oligosaccharides coated zinc nanocomposite (ZnOFNC) applied against nicotine tempted heart abnormalities. This scientific study was needed to establish a new nanocomposite, ZnOFNC (FOS coted zinc oxide nanocomposite), applied against nicotine entice heart abnormalities. ZnONPs and ZnOFNC synthesized through the green synthesis method were applied on an animal model. Required animals were (male albino rats, 100–120 gm bw) divided into six groups on the basis of toxic drugs (Nicotine) and therapeutic drugs (ZnOFNC, FOS, ZnONPs and vitamin C) treated for 15 days. The estimated parameters were biochemical parameters, electrocardiogram, platelets count and histological study. All the parameters of the ZnOFNC applied group result were satisfied with the control group than FOS, ZnONPs and vitamin C applied groups. Our result led us to conclude that the ZnOFNC may have the anti-nicotinic capability to protect the heart from nicotinic toxicity.