Synthesis, spectral characterization and antimicrobial effect of Cu(II) complexes of schiff Base Ligand, N-(3,4- dimethoxybenzylidene)-3-aminopyridine (DMBAP) Derived from 3,4-dimethoxybenzaldehyde and 3-aminopyridine

Abstract

The present study emphasizes strictly on the synthesis, and characterization of complex 3,4- dimethoxybenzaldehyde and 3-aminopyridine with Cu(II) using several techniques like Elemental Analysis, FTIR spectroscopy, NMR, HRMS, UV-vis spectroscopy, Magnetic Susceptibility and Conductivity Measurements. The Ligand [L] acts as bidentate and co-ordinates through Nitrogen atom of imine group [azomethine group] and Nitrogen atom of pyridine ring. Electronic data of the complexes suggest the probable geometry is octahedral in nature. All the complexes and ligand were screened for their antibacterial activity and behaved non-electrolytic in nature. The metal ligand ratio obeys 1:2 ratio. Antimicrobial studies of gram-positive bacteria (GPB)- (Bacillus subtilis), gram-negative bacteria (GNB)- (E. coli) and some antibiotic reveal the MIC value in the range of (6–20 mm) followed the order [Cu(L)2Cl2]>[Cu(L)2Br2]>Antibiotic>Ligand. Antimicrobial activity has been explained on the basis of Tweedy Chelation Theory (TCT) and Anil’s Conceptual Model of Inhibition (ACMI).